From Merida take Federal Highway 180 towards the junction with the Hoctun-Izamal Highway. Exit to the right and drive about 20 kilometers towards Izamal.
From Valladolid take Highway 295 to Highway 180D towards Merida until the junction with State Highway 11. Turn to the right towards Izamal and continue on the country road about 15 kilometers until you arrive in Izamal.
From CANCUN:
Take federal highway 180 towards MERIDA ( highway starts right behind Cancun Airport and is a tollway) and drive about 2 hours until you reach exit IZAMAL. Exit and continue about 15 kilometers on the country road until you arrive in Izamal.
Distance chart:
To Merida – 65 km
To Yucatan coast 55 km
To Chichen Itza - 65 km
To Uxmal - 95km
To Valladolid – 111 km
To Tulum - 235 km
To Cancun – 255 km
To Playa del Carmen - 235 km